Gap junctions in skeletal development and function
نویسندگان
چکیده
منابع مشابه
Gap junctions in development.
Almost since their discovery gap junctions have attracted attention as possible means by which cell growth and cell development could be controlled since they provide for direct cell-cell communication (Potter et al, 1966; Loewenstein, 1968; Sheridan, 1968; Crick, 1970; Bennett, 1973). A corollary, of course, is that gap junctions play an important role in embryogenesis. This idea is made espec...
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Connexin43 (Cx43), a major component of astrocytic gap junctions, is abundantly expressed in Bergmann glial cells (BGCs) in the cerebellum, but the function of Cx43 in BGCs is largely unknown. BGCs are specialized astrocytes closely associated with Purkinje cells. Here, we review our recent studies of the role of Cx43 in gap junctional coupling between BGCs and in cerebellar function. We genera...
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Gap junctions are sites of intercellular communication where cells are interconnected by small aqueous channels (Figure 1b). The term is morphological, for in transmission electron micrographs of thin sections, the unit membranes of the joined cells are seen to remain separated by a gap of about 2 nm (Figure 1a, inset). The gap of gap junctions distinguishes them from tight junctions, or zonula...
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Gap junctional intercellular communication plays a key role in the maintenance of homeostasis in multicellular organisms. Reflecting deranged homeostasis in cancer cells, most transformed or cancerous cells show aberrant gap junctional intercellular communication; they have decreased junctional communication between each other and/or with surrounding normal cells. Studies with in vitro cell tra...
متن کاملGap junctions
In vertebrates and invertebrates, signaling among neurons is most commonly mediated by chemical synapses. At these synapses neurotransmitter released by presynaptic neurons is detected by receptors on the postsynaptic neurons, leading to an influx of ions through the receptors themselves or through channels activated by intracellular signaling downstream of the receptors. But neurons can commun...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 2005
ISSN: 0005-2736
DOI: 10.1016/j.bbamem.2005.10.012